翻訳と辞書 Words near each other ・ Sample exclusion dimension ・ Sample grade ・ SAMPLE history ・ Sample in a Jar ・ Sample injector ・ Sample library ・ Sample Magic ・ Sample matrix inversion ・ Sample maximum and minimum ・ Samovila (village) ・ Samovodene ・ Samowicze ・ Samowo ・ Samoyed ・ Samoyed (dog) ・ Samoyed hereditary glomerulopathy ・ Samoyedic ・ Samoyedic languages ・ Samoyedic peoples ・ Samoyeds ・ Samoylov ・ Samoylovich Nunatak ・ Samoylovka ・ Samoylovsky ・ Samoylovsky (rural locality) ・ Samoylovsky District ・ Samoé ・ Samoëla ・ Samoëns ・ Samołęż Dictionary Lists mini英和辞書 mini和英辞書 Webster 1913 Latin-English FOLDOC Wikipedia English ウィキペディア

翻訳と辞書　辞書検索 [ 開発暫定版 ] スポンサード リンク Samoyed hereditary glomerulopathy ： ウィキペディア英語版 Samoyed hereditary glomerulopathy Samoyed hereditary glomerulopathy () (SHG) is an hereditary noninflammatory disease of the renal glomeruli, occurring in the Samoyed breed of dog. The disease has been shown to be a model for hereditary nephritis (HN) in humans in that the disease resembles that of the human disease. Because of this, it is sometimes referred to by the name given to the disease in humans when referring to the conditions in Samoyed dogs. Alternatively, it may also be known as X-linked hereditary nephritis. Genetically, the trait is inherited as a sex-linked, genetically dominant disease, and thus affects male dogs to a greater degree than female dogs, since males only have one X chromosome. ==Description== Samoyed Hereditary Glomerulopathy is caused by a nonsense mutation in codon 1027 of the COL4A5 gene on the X chromosome (glycine to stop codon), which is similar to Alport's syndrome in humans. The disease is simply inherited, X-linked dominant, with males generally having more severe symptoms than females. Clinically, from the age of three to four months, proteinuria in both sexes is seen. In dogs older than this, renal failure in combination with more or less pronounced hearing loss occurs swiftly, and death at the age of 8 to 15 months is expected. In heterozygous females, whereby only one of the two X chromosomes carry the mutation, the disease develops slowly.〔 The disease is specific to the Samoyed in that, the Samoyed, is the only breed of dog to show the more rapid progression to renal failure and death, as well as affecting males to a much more severe degree than females. The Samoyed, however is not the only breed of dog to suffer from life-threatening renal diseases. Proteinuria has been found consistently in Samoyeds, Doberman Pinschers, and Cocker spaniels. 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Samoyed hereditary glomerulopathy」の詳細全文を読む スポンサード リンク 翻訳と辞書 : 翻訳のためのインターネットリソース Copyright(C) kotoba.ne.jp 1997-2016. All Rights Reserved.